A growing amount of evidences indicates that inflammaging – the chronic, low grade inflammation state characteristic of the elderly – is the result of genetic as well as environmental or stochastic factors.
In their latest review Christine Nadini, Jean-François Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani and Maria Giulia Bacalini take a closer look how age related epigenetic changes promote inflammaging. Furthermore they discuss the role on envioronmental and microbial stimuli and how they can affect the rate of inflammaging via epigenetic mechanisms.
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